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Neurology Specialty Medications

MedRx Infusion dispenses specialty medications for multiple sclerosis, myasthenia gravis, CIDP, migraine and other neurological conditions, as infusions, injections and oral therapies. When the prescriber approves an infusion at home, MedRx delivers the medication at no charge and arranges a skilled nurse from an accredited nursing agency to administer it.

What is an MS infusion?

An MS infusion is a multiple sclerosis (MS) medication given slowly into a vein (intravenously) by a healthcare professional, such as Ocrevus (ocrelizumab) or Briumvi (ublituximab-xiiy). MedRx Infusion dispenses both to patients in 43 states, the District of Columbia and Puerto Rico, and therapy starts when the prescriber's office sends a referral.

Ocrevus and Briumvi are monoclonal antibodies (lab-made proteins) that attach to CD20, a marker on B cells, and lower the number of these immune cells. Solu-Medrol (methylprednisolone sodium succinate), a corticosteroid, is also given intravenously; its label's use in MS is a sudden flare-up (relapse).

MedRx Infusion Clinical Pharmacy is a specialty pharmacy and a home infusion pharmacy. Beyond MS, it dispenses medications for myasthenia gravis, chronic inflammatory demyelinating polyneuropathy (CIDP) and migraine.

Neurology medications MedRx dispenses, by condition

Each medication is FDA-approved for its own conditions, and the prescriber determines which is appropriate:

  • Relapsing forms of MS: Ocrevus and Briumvi, intravenous; Kesimpta (ofatumumab), and Copaxone and Glatopa (both glatiramer acetate), injected under the skin (subcutaneously); and Zeposia (ozanimod), a capsule taken by mouth.
  • Primary progressive MS, and relapsing-remitting MS in children 10 years and older: Ocrevus.
  • A sudden flare-up of MS: Solu-Medrol, intravenous or into a muscle.
  • Generalized myasthenia gravis: Vyvgart (efgartigimod alfa-fcab), Imaavy (nipocalimab-aahu), Soliris (eculizumab), Ultomiris (ravulizumab-cwvz) and Uplizna (inebilizumab-cdon), intravenous; Vyvgart Hytrulo (efgartigimod alfa and hyaluronidase-qvfc) and Zilbrysq (zilucoplan), subcutaneous injections; and Rystiggo (rozanolixizumab-noli), a subcutaneous pump infusion. Several of these labels cover only patients positive for anti-acetylcholine receptor (AChR) or anti-muscle-specific kinase (MuSK) antibodies.
  • Neuromyelitis optica spectrum disorder (NMOSD), anti-aquaporin-4 antibody positive: Soliris, Ultomiris and Uplizna.
  • CIDP: the intravenous immune globulins (IVIG) Gamunex-C, Gammaked, Gammagard Liquid, Privigen and Panzyga; the subcutaneous immune globulins (SCIG) Hizentra and HyQvia, as maintenance therapy after IVIG; and Vyvgart Hytrulo. See IVIG for neuromuscular disorders.
  • Multifocal motor neuropathy (MMN): Gammagard Liquid, intravenous, as maintenance therapy.
  • Migraine prevention: Aimovig (erenumab-aooe), Ajovy (fremanezumab-vfrm) and Emgality (galcanezumab-gnlm), subcutaneous injections; Vyepti (eptinezumab-jjmr), intravenous; Nurtec ODT (rimegepant), by mouth, for episodic migraine; and Botox (onabotulinumtoxinA), injected into muscle, for chronic migraine.
  • A migraine attack: Nurtec ODT; Zembrace SymTouch (sumatriptan), a subcutaneous auto-injector; and dihydroergotamine (DHE), intravenous, into a muscle or under the skin.
  • Cluster headache: Emgality, for episodic cluster headache in adults, and dihydroergotamine, to treat an episode.
  • Spasticity and cervical dystonia: Botox.
  • "Off" episodes in Parkinson's disease: Ongentys (opicapone), by mouth with levodopa/carbidopa.

Soliris, Ultomiris and Zilbrysq are available only through REMS safety programs the FDA requires; MedRx Infusion is certified to dispense all three. The full list, with a page for each medication, follows at the end of this page.

Where neurology medications are given

When the prescriber approves an infusion at home, MedRx sends a skilled, trusted and licensed nurse from an accredited nursing agency to administer it and monitor vital signs and adverse reactions throughout. See biologic infusions at home.

Kesimpta, Copaxone, Zilbrysq, the migraine injections and subcutaneous immune globulin, infused with a small pump, can be given by the patient or a caregiver after training; a nurse can teach the technique. Rystiggo's pump infusion is given by a healthcare professional.

Some labels limit where a medication is given, and the prescriber determines the setting:

  • Ocrevus, Briumvi and Uplizna: the labels call for close supervision by an experienced healthcare professional and premedication to lower the risk of infusion reactions, with at least an hour of observation after each Ocrevus or Uplizna infusion and after the first two Briumvi infusions.
  • Vyepti and Botox: Vyepti is given by a healthcare provider in a healthcare setting, as its label requires, and Botox is injected by a doctor trained in these injections, usually in the office or clinic. MedRx Infusion dispenses them for the setting where they are given.
  • Zembrace SymTouch and dihydroergotamine: for patients with risk factors for heart disease, the labels call for the first dose in a medically supervised setting.

How to refer a patient for a neurology medication

  1. The prescriber's office faxes the prescription to (844) 671-2601 or calls (844) 671-2600, with recent clinical notes and laboratory results, on the Multiple sclerosis referral form (PDF), the Migraine referral form (PDF), the Neurology referral form (PDF) for the myasthenia gravis and NMOSD medications, or the Immunoglobulin referral form (PDF) for IVIG and SCIG. All are on Quick Referral.
  2. The form records where the medication will be given (the patient's home, the prescriber's office or elsewhere), and the office can ask MedRx to hold the shipment until it is ready.
  3. MedRx's intake team verifies insurance benefits and obtains prior authorization when the plan requires it.
  4. The medication and supplies are delivered to the patient's door at no charge. Next-day delivery is available; timing varies by location.
  5. A MedRx pharmacist is available 24 hours a day, 7 days a week.

Insurance and cost

Many health plans require prior authorization before they cover MS infusions and the other neurology biologics. MedRx's intake team checks the patient's benefits and completes the paperwork with the prescriber's office before the first delivery.

When out-of-pocket costs are a barrier, MedRx helps patients apply for copay assistance, grants and other financial aid. Manufacturers also run patient support programs, among them Ocrevus Connects, Alexion OneSource for Soliris and Ultomiris, and My Vyvgart Path; each medication page names its program.

Key facts

Organization
MedRx Infusion Clinical Pharmacy
What we do
A home infusion pharmacy and specialty pharmacy, with infusion nurses who visit patients at home and a pharmacist on call 24 hours a day, 7 days a week.
Where
Pharmacy at 417 N Oak St, Inglewood, CA 90302. Licensed in 43 states, the District of Columbia and Puerto Rico. See every place we serve
Accreditation
URAC (Specialty Pharmacy) and ACHC (Accreditation Commission for Health Care).
Phone, 24 hours
(844) 671-2600
Fax
(844) 671-2601

Accurate as of

Questions about neurology medications

01What are the infusion drugs for MS?

The intravenous MS medications MedRx dispenses are Ocrevus and Briumvi, both FDA-approved for relapsing forms of MS; Ocrevus is also approved for primary progressive MS. Solu-Medrol, an intravenous corticosteroid, is used for a sudden flare-up. The prescriber chooses the treatment.

02What is Ocrevus infusion used for?

Ocrevus is FDA-approved for adults with relapsing forms of MS, including clinically isolated syndrome, relapsing-remitting MS and active secondary progressive MS, and for adults with primary progressive MS. It is also approved for relapsing-remitting MS in children 10 years and older who weigh at least 25 kg.

03Can Ocrevus be infused at home?

It can be, when the prescriber determines that home infusion is appropriate. MedRx delivers the medication at no charge and sends a nurse from an accredited nursing agency to administer it under the conditions its label sets.

04What should patients expect during an Ocrevus infusion?

Ocrevus is given intravenously after premedication to lower the risk of infusion reactions, under close supervision by an experienced healthcare professional. The patient is observed for at least an hour after each infusion. At home, the nurse also monitors vital signs and adverse reactions throughout.

05How much does an MS infusion cost?

The cost depends on the medication and the patient's health plan, and many plans require prior authorization first. MedRx's intake team verifies benefits before the first delivery and helps patients apply for copay assistance, including the manufacturer's program, such as Ocrevus Connects or Briumvi Patient Support.

Medications we fill

Each has its own page: what it is approved for, how it is given, and how to start. See every medication we fill.

Send a referral

Intake handles benefits investigation, prior authorization and scheduling.

Send a referral

Phone

(844) 671-2600

Speak with an intake coordinator

Fax

(844) 671-2601

Send a completed referral form

Forms

Referral forms

Specialty-specific PDFs