Infectious Disease Medications

Every medication in this list is taken by mouth.

• Hepatitis C: Mavyret (glecaprevir and pibrentasvir), Epclusa (sofosbuvir and velpatasvir) and its authorized generic, Harvoni (ledipasvir and sofosbuvir) and Vosevi (sofosbuvir, velpatasvir and voxilaprevir), each a combination of direct-acting antivirals. Mavyret and Epclusa are approved for genotypes 1 to 6 and Harvoni for genotypes 1, 4, 5 and 6; Mavyret also for acute infection. Vosevi is for adults treated for hepatitis C before.
• Chronic hepatitis B: Vemlidy (tenofovir alafenamide), for adults and children 6 years and older who weigh at least 25 kg (55 pounds) and have compensated liver disease (the liver still works well enough).
• C. diff diarrhea: Dificid (fidaxomicin), for adults and children 6 months and older with diarrhea caused by Clostridioides difficile bacteria.
• Travelers' diarrhea: Xifaxan (rifaximin), for adults and children 12 years and older when the cause is a noninvasive strain of E. coli, not for diarrhea with fever or blood in the stool.

The prescriber chooses the regimen; for hepatitis C, by genotype, earlier treatment and whether the patient has cirrhosis. Each medication's own page is linked at the end of this page.

Outpatient parenteral antimicrobial therapy (OPAT) is intravenous antibiotic or antifungal treatment given outside the hospital. MedRx Infusion dispenses IV anti-infectives in several drug classes for infections such as bone and joint, bloodstream and complicated urinary tract infections, and arranges a nurse to give them at home when the prescriber approves. Who qualifies, the medications and each step of home therapy are set out on IV antibiotics at home.

The hepatitis C and B antivirals, Dificid and Xifaxan are taken at home. MedRx ships them to the patient's door at no charge. Next-day delivery is available; timing varies by location.

IV antibiotics and antifungals are given at home by a skilled, trusted and licensed nurse from an accredited nursing agency, when the prescriber approves home therapy. A MedRx pharmacist is available 24 hours a day, 7 days a week.

1. The prescriber's office faxes or phones in the prescription with the Hepatitis C referral form (PDF) or the Hepatitis B referral form (PDF), with recent clinical notes and laboratory results. For Dificid and Xifaxan, use Quick Referral.
2. MedRx's intake team confirms the patient's benefits and requests prior authorization if the plan requires it.
3. A MedRx pharmacist reviews the prescription and monitors for drug interactions.
4. The medication is delivered to the patient's door at no charge. Next-day delivery is available; timing varies by location.

The hepatitis C form asks for the genotype, viral load, fibrosis score, cirrhosis status and prior therapies, and the hepatitis B form for the viral load, fibrosis score and prior therapies. Before a hepatitis C antiviral, the prescriber tests for current or past hepatitis B: all four labels carry a boxed warning about hepatitis B reactivation. Vemlidy's label calls for HIV and kidney function tests first.

Health plans often require prior authorization for specialty medications such as hepatitis C antivirals. MedRx's intake team checks coverage and confirms approval with the prescriber's office before the first delivery.

When out-of-pocket costs are hard to meet, MedRx helps patients apply for copay assistance, grants and other financial help. Manufacturer programs for eligible patients include the Mavyret Savings Card, Gilead Support Path (Epclusa's authorized generic, Harvoni, Vosevi and Vemlidy) and the Xifaxan Instant Copay Savings Card.

• IV antibiotics and antifungals: every IV antibiotic and antifungal we fill.
• Hepatitis C: Mavyret, Sofosbuvir and Velpatasvir, Harvoni and Vosevi.
• Hepatitis B: Vemlidy.
• Gut infections: Dificid and Xifaxan.

Each has its own page: what it is approved for, how it is given, and how to start. See every medication we fill.