SCIG Home Infusion

Subcutaneous immunoglobulin (SCIG) is immune globulin infused under the skin with a small pump. MedRx Infusion dispenses SCIG, delivers it with the supplies at no charge, and can send a skilled nurse from an accredited nursing agency to train the patient or caregiver to give it at home.

What is SCIG?

SCIG is immune globulin given subcutaneously, under the skin. Immune globulin is a medication made from human plasma that supplies IgG antibodies, the proteins that help fight infection.

SCIG is infused through a small needle with a small pump. After training, the patient or a caregiver can give it at home.

MedRx Infusion Clinical Pharmacy is a home infusion and specialty pharmacy, serving patients in 43 states, the District of Columbia and Puerto Rico. Therapy starts with a referral from the prescriber's office.

Who SCIG is for

SCIG is FDA-approved for:

Primary humoral immunodeficiency (PI): a group of conditions, often inherited, in which the body does not make enough working antibodies. Hizentra, Xembify, Gammagard Liquid and Gamunex-C are approved for subcutaneous use in PI in adults and children 2 years and older. See primary immunodeficiency.
Chronic inflammatory demyelinating polyneuropathy (CIDP): a nerve condition that causes weakness and numbness in the arms and legs. Hizentra is approved for adults with CIDP as maintenance therapy to prevent relapse, started after treatment with intravenous immune globulin. See nerve and muscle conditions.

The prescriber determines whether SCIG is appropriate.

SCIG products MedRx dispenses

Hizentra and Xembify are for subcutaneous use only.
Gammagard Liquid and Gamunex-C can be given subcutaneously or intravenously. Their subcutaneous use is for PI.

Some SCIG products are stored in the refrigerator and some at room temperature. Each medication page gives its storage and approved uses.

How SCIG at home works

The prescriber's office faxes or phones in a referral. The Immunoglobulin Referral Form (PDF) should go with recent clinical notes and laboratory results.
MedRx's intake team verifies insurance benefits and obtains prior authorization when the plan requires it.
Medication and supplies are delivered to the patient's door at no charge. Depending on the therapy, supplies include needles, tubing and an infusion pump. Next-day delivery is available; timing varies by location.
A skilled, trusted and licensed nurse from an accredited nursing agency visits the patient's home. The nurse can administer the infusion and train the patient or caregiver to give it.
After training, the patient or caregiver gives SCIG at home on the schedule the prescriber sets.
A MedRx pharmacist is available 24 hours a day, 7 days a week.

Switching from IVIG

Intravenous immunoglobulin (IVIG) is immune globulin given into a vein. The prescriber may move a patient from IVIG to SCIG and determines which route is appropriate.

Before a switch, the prescriber may check the patient's IgG antibody level with a blood test. For PI, the Hizentra label calls for regular intravenous immune globulin for at least 3 months first. For CIDP, Hizentra is started after treatment with intravenous immune globulin.

For a patient already on IVIG, MedRx's intake team works with the prescriber's office on the change. See IVIG at home.

Insurance and cost

Health plans often require prior authorization for immune globulin. MedRx's intake team checks coverage and works with the prescriber's office on the paperwork before the first delivery.

Where out-of-pocket costs are a barrier, MedRx helps patients find and apply for copay assistance, grants and other financial aid. The manufacturers of Hizentra, Xembify, Gammagard Liquid and Gamunex-C also run support programs; each medication page names its program.

Key facts

Organization: MedRx Infusion Clinical Pharmacy
What we do: A home infusion pharmacy and specialty pharmacy, with infusion nurses who visit patients at home and a pharmacist on call 24 hours a day, 7 days a week.
Where: Pharmacy at 417 N Oak St, Inglewood, CA 90302. Licensed in 43 states, the District of Columbia and Puerto Rico. See every place we serve
Accreditation: URAC (Specialty Pharmacy) and ACHC (Accreditation Commission for Health Care).
Phone, 24 hours: (844) 671-2600
Fax: (844) 671-2601

Accurate as of October 19, 2026

Questions about SCIG

01What is SCIG?

SCIG is subcutaneous immunoglobulin: immune globulin infused under the skin with a small pump. It is made from human plasma and supplies IgG antibodies, which help fight infection. After training, the patient or a caregiver can give it at home.

02Can SCIG be self-administered at home?

Yes, after training, when the prescriber agrees. A skilled nurse from an accredited nursing agency can visit the home and train the patient or caregiver. A MedRx pharmacist is available 24 hours a day, 7 days a week.

03Can a patient switch from IVIG to SCIG?

The prescriber decides. Before a switch, the prescriber may check the patient's IgG antibody level with a blood test. For a patient already on IVIG, MedRx's intake team works with the prescriber's office on the change.

04What supplies does SCIG at home require?

Depending on the therapy, the medication, needles, tubing and an infusion pump. MedRx delivers the medication and supplies to the patient's door at no charge.

05Which SCIG products does MedRx dispense?

MedRx Infusion dispenses Hizentra, Xembify, Gammagard Liquid and Gamunex-C on prescription.

06Does insurance cover SCIG at home?

Coverage depends on the plan and the medication. Many plans require prior authorization. MedRx's intake team checks coverage before the first delivery and can help patients look for copay assistance.