Nucala (mepolizumab)

• Severe asthma: adults and children 6 years and older with severe asthma that is the eosinophilic type (linked to high levels of eosinophils); used as an add-on maintenance treatment (taken along with your other daily medicines), not for sudden breathing problems.
• Chronic rhinosinusitis with nasal polyps (CRSwNP): adults 18 years and older with nasal polyps (growths in the nose and sinuses) that did not respond well enough to steroid nose sprays; used as an add-on maintenance treatment.
• COPD: adults with chronic obstructive pulmonary disease (COPD, a long-term lung disease) that is not well controlled and is the eosinophilic type; used as an add-on maintenance treatment, not for sudden breathing problems.
• Eosinophilic granulomatosis with polyangiitis (EGPA): adults with EGPA (a rare disease that causes swelling of blood vessels and high eosinophil levels).
• Hypereosinophilic syndrome (HES): adults and children 12 years and older who have had HES (very high eosinophil levels that can harm organs) for 6 months or longer, when no other cause outside the blood has been found.

A prescription is required. Your prescriber decides whether Nucala is right for you.

Injection under the skin, given by a healthcare professional, or you or a caregiver after training. A nurse can show you or a caregiver how to give it.

Storage: Keep pens and prefilled syringes in the refrigerator in the original carton to protect them from light; do not freeze or shake them. If needed, an unopened carton can stay at room temperature (up to 86°F) for up to 7 days.

Before the first dose, your prescriber may ask for:

• treatment first of any worm (helminth) infection you already have

Read the Medication Guide and the full Nucala prescribing information, and ask your prescriber or our pharmacists about side effects. Our pharmacists are on call 24 hours a day.

Health plans often require prior authorization for Nucala. Our intake team checks your coverage and works with your prescriber’s office on the paperwork before your first delivery.

The manufacturer runs a support program, Together with Nucala, that may help eligible patients with costs and access.

Offices can call (844) 671-2600 or fax a referral to (844) 671-2601. Use the Allergy and Asthma Referral Form (PDF).

The manufacturer also publishes Together with Nucala enrollment form.