Methotrexate (methotrexate)

Filled with a prescription and delivered free to your door, with help on prior authorization.

Methotrexate is a folate analog metabolic inhibitor, a medicine that blocks the body's use of folate (a B vitamin). This slows down fast-growing cells, such as cancer cells; how it works in arthritis and psoriasis is not known.

MedRx Infusion can fill Methotrexate with a prescription and deliver it free to your door.

What Methotrexate is prescribed for

Acute lymphoblastic leukemia (ALL): adults and children with ALL (a fast-growing blood cancer), as part of a combination chemotherapy regimen.
Meningeal leukemia: adults and children, to prevent or treat leukemia that has spread to the lining of the brain and spinal cord.
Non-Hodgkin lymphoma: adults and children with non-Hodgkin lymphoma (a cancer of the lymph system).
Osteosarcoma: adults and children with osteosarcoma (a bone cancer), as part of a combination chemotherapy regimen.
Breast cancer: adults with breast cancer, as part of a combination chemotherapy regimen.
Head and neck cancer: adults with squamous cell carcinoma of the head and neck, as the only cancer medicine (single agent).
Gestational trophoblastic neoplasia (GTN): adults with GTN (tumors that grow from tissue that forms during pregnancy), as part of a combination chemotherapy regimen.
Rheumatoid arthritis: adults with rheumatoid arthritis (RA).
Polyarticular juvenile idiopathic arthritis (pJIA): children with pJIA (arthritis in many joints that starts in childhood).
Severe psoriasis: adults with severe psoriasis (a skin condition with thick, scaly patches).

A prescription is required. Your prescriber decides whether Methotrexate is right for you.

How Methotrexate is given

IV infusion, given by a healthcare professional. When your prescriber agrees it can be given at home, we send a skilled nurse from an accredited nursing agency to give it.

Injection into a muscle, given by a healthcare professional. When your prescriber agrees it can be given at home, we send a skilled nurse from an accredited nursing agency to give it.

Injection under the skin, given by a healthcare professional. When your prescriber agrees it can be given at home, we send a skilled nurse from an accredited nursing agency to give it.

Before you start

Before the first dose, your prescriber may ask for:

a pregnancy test for women who can become pregnant
blood counts (a complete blood count)
blood tests of liver function
for high-dose treatment, blood tests of kidney function and electrolytes (body salts)
vaccines brought up to date
draining of large fluid build-ups, such as fluid around the lungs or in the belly, if you have them

Important safety information: This medicine has a boxed warning about harm to an unborn baby, including death, and about serious allergic reactions. It also warns that vials with the preservative benzyl alcohol can cause serious nerve and blood-acid problems, and that other serious side effects, including death, can happen, such as infections and harm to the bone marrow, kidneys, liver, nerves, gut, lungs and skin.

Read the Medication Guide and the full Methotrexate prescribing information, and ask your prescriber or our pharmacists about side effects. Our pharmacists are on call 24 hours a day.

Insurance and prior authorization

Health plans often require prior authorization for Methotrexate. Our intake team checks your coverage and works with your prescriber’s office on the paperwork before your first delivery.

How to refer a patient

Offices can call (844) 671-2600 or fax a referral to (844) 671-2601. Use the Rheumatology Referral Form (PDF).

Questions

01Does MedRx Infusion fill Methotrexate?

Yes. MedRx Infusion can fill Methotrexate with a prescription and deliver it free to your door. Our intake team confirms access and coverage for each patient.

02What is Methotrexate used for?

Methotrexate is approved for acute lymphoblastic leukemia (ALL), meningeal leukemia, non-Hodgkin lymphoma, osteosarcoma, breast cancer, head and neck cancer, gestational trophoblastic neoplasia (GTN), rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA) and severe psoriasis. Your prescriber decides whether it is right for you.

03Can Methotrexate be given at home?

It can be, when your prescriber agrees. We send a skilled nurse from an accredited nursing agency to give Methotrexate at home.

04Does insurance cover Methotrexate?

Coverage depends on your health plan, and many plans require prior authorization. Our intake team checks your coverage before your first delivery.

See all the medications we fill.