Krystexxa (pegloticase)

• Chronic gout: adults with long-lasting (chronic) gout that standard uric acid-lowering pills (xanthine oxidase inhibitors) did not control, or who cannot take those pills.

A prescription is required. Your prescriber decides whether Krystexxa is right for you.

IV infusion, given by a healthcare professional.

The label says Krystexxa is given in a healthcare setting by providers prepared to manage serious allergic reactions. Ask your prescriber where you will get it.

Before the first dose, your prescriber may ask for:

• a blood test for G6PD deficiency (an inherited enzyme problem that can harm red blood cells), if you are at risk for it
• a blood test for uric acid, which is checked before each infusion

Important safety information: This medicine has a boxed warning about serious allergic reactions (anaphylaxis) and infusion reactions. It also warns about red blood cell breakdown (hemolysis) and a blood problem called methemoglobinemia in people with G6PD deficiency, who must not get Krystexxa.

Read the Medication Guide and the full Krystexxa prescribing information, and ask your prescriber or our pharmacists about side effects. Our pharmacists are on call 24 hours a day.

Health plans often require prior authorization for Krystexxa. Our intake team checks your coverage and works with your prescriber’s office on the paperwork before your first delivery.

The manufacturer runs a support program, Amgen By Your Side, that may help eligible patients with costs and access.

Offices can call (844) 671-2600 or fax a referral to (844) 671-2601. Use the Rheumatology Referral Form (PDF).

The manufacturer also publishes Krystexxa patient enrollment forms and resources.